Brent Y. Chick

Selected peer-reviewed publications. Full list on Google Scholar.

• Atlas-guided discovery of transcription factors for T cell programming

  Chung HK, Chen S, Engel BJ, Bhatt RR, Li Y, Fang Q, Yang S, Zhang C, Coles GL, Bhatt DL, Pan X, Li Y, Li T, Rathore APS, Wen D, Adachi K, Song L, Chick BY, Hargreaves DC, Zhang K, Bhatt DL, Wang W. Nature, 2026.

• The antiviral interferon pathway drives astrocyte aging and motor decline

  Labarta-Bajo L, Bhatt DL, Bhatt RR, Ye H, Chick BY, Hargreaves DC, Allen NJ. bioRxiv, 2025.

• RNA polymerase II promoter-proximal pausing promotes BAF chromatin binding and remodeling

  Chick BY, Hargreaves DC. Nature Genetics, 2024 (invited commentary).

• Canonical BAF complex activity shapes the enhancer landscape that licenses CD8⁺ T cell effector and memory fates

  McDonald B†, Chick BY†, Ahmed MY, Burns E, Ma S, Casero D, Bhatt DL, Kaech SM. Immunity, 2023 (†co-first author).

• Early chromatin remodeling events in acutely stimulated CD8⁺ T cells

  McDonald B†, Chick BY†, Hargreaves DC, Kaech SM. Yale Journal of Biology and Medicine, 2023 (†co-first author).

• Switching under selection: how CoREST controls endocrine therapy resistance in ER+ breast cancer

  Chick BY, Hargreaves DC. Nature Structural & Molecular Biology, 2022 (invited commentary).

• In vitro recapitulation of murine thymopoiesis from single hematopoietic stem cells

  Montel-Hagen A, Sun V, Casero D, Tsai S, Zampieri A, Jackson N, Li S, Lopez S, Zhu Y, Chick B, He C, de Barros SC, Seet CS, Crooks GM. Cell Reports, 2020.

• Pleiotropic roles of VEGF in the microenvironment of the developing thymus

  de Barros SC, Suterwala BT, He C, Ge S, Chick B, Blumberg GK, Kim K, Klein S, Zhu Y, Wang X, Casero D, Crooks GM. The Journal of Immunology, 2020.

• Organoid-induced differentiation of conventional T cells from human pluripotent stem cells

  Montel-Hagen A, Seet CS, Li S, Chick B, Zhu Y, Chang P, Tsai S, Sun V, Lopez S, Chen HC, He C, Chin CJ, Casero D, Crooks GM. Cell Stem Cell, 2019.

• Notch signaling regulates the differentiation of CLEC9A+ dendritic cells (cDC1) from human and mouse hematopoietic stem/progenitor cells

  Seet CS, Li S, Chick B, Casero D, Kim J, Gschweng E, Chen HC, Zhu Y, Lopez S, Miao R, Montel-Hagen A, Kohn D, Sehl M, Crooks GM. Experimental Hematology, 2018.

• Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids

  Seet CS, He C, Bethune MT, Li S, Chick B, Gschweng EH, Zhu Y, Kim K, Kohn DB, Baltimore D, Crooks GM, Montel-Hagen A. Nature Methods, 2017.